The Dangers of CBD in Young People and its Benefits

Posted on , by Damien

For a few years, in France and in the rest of the world, we hear more and more about “light cannabis”. This term is used to refer to a product containing cannabidiol (CBD). It refers to this plant so stigmatized that is cannabis (hemp). As a result of this confusion, this cannabis still often leads to controversy. Indeed, the word “cannabis” almost systematically refers to weed, grass, weed, marijuana, ganja and other terms designating this well-known drug!

The marketing of CBD products (

hemp oil

resin, e liquids with CBD…) seems then for some:

  • something that should be illegal
  • because it is dangerous
  • since it comes from a stupefying plant according to the French law.

In reality, CBD is a compound of hemp. But, it is not this molecule that has earned cannabis its place on the list of narcotics. Alas, beliefs are tenacious! And as a result, products containing CBD are still in the news for a long time.potential anger.

What is really going on: Are there any dangers to consuming CBD?

A little tour around the cannabinoids CBD and THC

A plant such as cannabis contains many active compounds:

  • cannabinoids,
  • terpenes
  • and flavonoids.

Among the best known and most concentrated cannabinoids are THC (tetrahydrocannabinol) and
CBD
(cannabidiol).

THC acts directly on

cannabinoid receptors

our body. As a result, it interferes with their normal functioning. On the other hand, CBD does not disrupt the endocannabinoid system. It would even stimulate it! It is therefore the harmful psychotropic effects of THC that have demonized cannabis. Indeed, industrial hemp (textile and building) has never created a controversy. However, it is also cannabis. It is all a question of varieties and therefore of genetic composition. Well, for CBD, it’s the same thing!

To be legal, CBD products found on the market must come from varieties of hemp authorized by the order of August 22, 1990 (1). These varieties have as main specificity:

  • a THC level lower than 0,2%.

Given their residual contents of psychotropic substance (THC)(THC), their consumption does not cause high or euphoric effects.

Opinions and testimonials on CBD

In November 2017, a WHO report, executed following a meeting of drug addiction experts, clarified the health situation of CBD:

  • If this molecule can in no way be considered at the moment as a drug (studies in progress), it would not lead to any addiction and would not be harmful to health (2).

Based on this report and on the many testimonies of consumers of CBD products (oils, liquids for an electronic cigarette, seeds, flowers, balms, …), this substance extracted from cannabis would not present any danger.

Side effects and dangers of CBD

As the saying goes, “the exception proves the rule”. In fact, some scientific studies and rare testimonies reveal more or less important side effects of CBD:

– If the benefits of CBD are very diverse according to the opinions (anti pain, relaxation of the body and mind, …), the decrease of anxiety and insomnia are the main virtues that come back unceasingly in the testimonies of consumers. This muscular relaxation that CBD provides can sometimes cause for sensitive people, a slight drowsiness putting a person in a vaseous state making it unfit for concentration. If this effect may seem non-existent for CBD users, it is however not recommended to consume it just before undertaking an activity requiring concentration, such as driving, in order to avoid all risks of accidents.

Medical advice and CBD

The National Agency for Medicines and Health Products (ANSM) publishes in January 2019, an information point regarding the use of CBD in the treatment of epilepsy :

  • “While it may be of interest in the treatment of some severe forms of epilepsy, CBD has psychoactive effects, can be potentially toxic to the liver, and is likely to increase body levels of certain drugs, especially anti-epileptics, with the risk of increasing their toxicity. ” (3)

Scientific research published in April 2019 in the journal “Molecule” supports this point of information. Large doses of CBD are administered to mice to test its potential toxicity. The overdose of CBD undergone by the animals reveals important hepatic disorders (4) being able to lead to the death in certain subjects.

CBD is not addictive. There is no need to increase the recommended optimal dose. Indeed, nothing will happen in addition! An overdose of CBD causing liver intoxication in humans is therefore unlikely.

CBD does not reveal any toxicity as a pure molecule. However, it can potentially interact with pre-existing drugs. So beware of self-medication! This practice can sometimes be harmful to your health.

Before taking a CBD product as a therapeutic treatment, it is preferable to inform your doctor beforehand.

Contra indication of CBD

CBD has hypotensive properties. Therefore, its consumption should be avoided by people with low blood pressure.

Due to a lack of hindsight and extensive studies on the development of the fetus in the presence of cannabidiol in the body, it is not recommended that pregnant women take CBD products. And this, whatever their form (balm, hemp seeds, cannabis oil, …).

For obvious reasons, the sale of CBD products from specialized shops is prohibited to minors. Only doctors can, Since the beginning of December 2018, prescribe a treatment such as

Epidyolex

. Indeed, the use of CBD-based drugs such as Epidyolex, is authorized temporarily and by name by the ANSM (ATU: Temporary Use Authorizations) in certain severe forms of epilepsy in children.

Weight loss as a danger of CBD?

Some side effects are sometimes listed among user testimonials:

  • nausea,
  • temporary numbness,
  • diarrhea,
  • irritability
  • and changes in appetite

If these remarks are not harmless, it is important to remember that paradoxically, CBD is often used to fight against these discomforts. Once again, some exceptions prove the rule!

The benefits of CBD

Ok! This list of potential dangers of CBD listed above can be scary! However, it is necessary to take all the criteria into account before crying wolf!

In most of the stated disorders, the dose of CBD ingested (low, optimal, overdose), the quality of CBD products and the type of consumption (cigarette, inhalation, vaping, …) are very influential factors:

  • In the same way that too much chocolate is disgusting, taking too much CBD can potentially cause drowsiness or nausea.
  • A CBD product of poor quality, whatever it is (hemp oil, cannabis flowers, seeds, CBD resin, …), of which we know neither the origin, nor the manufacturing process, can generate risks. But the culprits are the chemicals (pesticides, CBD booster, solvents, …) potentially present, not the CBD. It is very important when buying CBD products that the store can provide traceability information (from the variety of cannabis used to the finished product). If in doubt, skip it! In addition to health problems, you could be buying a narcotic product (THC level above 0.2%) and putting yourself outside the law.
  • For smokers, consuming cannabis flowers or resin in a cigarette will cause the same vascular, respiratory and carcinogenic risks as tobacco (combustion phenomenon). Inhalation, vaporization, vaping, ingestion and skin application are the preferred methods of absorption. Get the most out of the benefits of CBD, without putting your health at risk. It’s not bad, is it?

In France as in many countries in Europe, the consumption of CBD products is booming. Finally, when we count the majority of opinions concerning the side effects of this use, the most common answer is, that there are none! Non psychotropic, CBD does not cause a change in the state of consciousness. It also does not lead to addiction or dependence. Finally, it has no proven toxicity.

To conclude…

At the moment, CBD is not a drug. But, it is not a medicine either! However, numerous studies have revealed its benefits. France should also, from the beginning of 2021, set up supervised tests on patients, with cannabis as a therapeutic treatment. It is clear that CBD still has a long way to go.

FAQ: The dangers of CBD

La molécule de CBD en tant que telle n'est pas mauvaise pour les poumons.

Si certains rapprochements sont parfois hâtivement émis, c'est à cause du type de consommation de certains utilisateurs de CBD.

Rappelons le : le CBD vient du chanvre et le chanvre peut se fumer! C'est bien ce mode de consommation qui pose problème. Comme pour le tabac, fumer du CBD peut entraîner des problèmes pulmonaires (entre autres) à cause de la fumée inhalée.

C'est la combustion du CBD qui est mauvaise pour la santé et non le CBD!

Le cannabidiol (CBD) est particulièrement connu pour ses effets relaxants menant au bien être. Ne serait-ce que pour cette qualité, on peut affirmer que le CBD est bon pour la santé.

De plus, la détente que procure le CBD est essentiellement due à son effet :

  • analgésique
  • anxiolytique
  • anti-nauséeux
  • anti-inflammatoire

Autant d'effets qui confirment les bienfaits du CBD pour la santé. Pour autant, fumer du CBD pose un problème dans la balance bénéfices/risque quant à la santé. Cependant, ce problème vient du mode de consommation (fumer) et non du CBD en tant que tel.

Contrairement au THC, le CBD n’a pas véritablement d’affinités avec les récepteurs endocannabinoïdes de notre système endocannabinoïde (SEC). Il ne se fixe pas sur eux mais a une action sur une enzyme bien spécifique appelée FAAH (fatty acid amid hydrolase). C’est elle qui régule la concentration de l’anandamide en la dégradant.

En présence de CBD, la FAAH est gênée dans sa fonction. Il en résulte une augmentation significative de la concentration d’anandamide d'où l'effet relaxant ressenti par le consommateur. 

Les nombreuses propriétés du CBD permettent de soulager efficacement le quotidien de ses consommateurs. Si dans la majeure partie des cas le CBD est consommé pour se relaxer, il peut également accompagner certains patients dans leur pathologie :

  • soulage certaines douleurs articulaires (arthrose, arthrite, ..) et musculaires (fibromyalgie, ..)
  • diminue le stress, anxiété, angoisse (dépression, burn-out, insomnies ..)
  • réduit les nausées (chimiothérapie, mal du transport,..)
  • régule l'appétit (cancer, troubles alimentaires, ..)
  • sert de leurre à l'addiction au cannabis, etc...

Malgré toutes ces vertus, le CBD n'est pas un médicament, il ne soigne pas! 

 

Le CBD ne possède peu ou pas d'effets secondaires. Il n'appartient pas à la liste des substances stupéfiantes toxiques. Cependant, dans de rares cas, des effets temporaires bénins peuvent apparaître après une consommation de CBD. Parmi ceux là, on note le plus souvent une sécheresse buccale, des troubles digestifs et une somnolence. 

Afin d'éviter des risques inutiles liés à la détente que le CBD confère et en cas de doutes, il est alors déconseillé de consommer du CBD avant de conduire. De la même façon que pour n'importe quel produit, il est important d'acheter des produits au CBD de bonne qualité pour minimiser les risques liés aux composants douteux et potentiellement nocifs pour la santé.

Des études scientifiques démontrent que le CBD diminuerait : 

  • le rythme cardiaque
  • la pression artérielle
  • l'inflammation

Cette molécule favorise la circulation sanguine à la manière d'un vasodilatateur.

A moins de contre indications médicales spécifiques, le CBD n'est potentiellement pas dangereux pour le cœur.

En France, il n'existe aucun statut particulier pour vendre du CBD légal dans un magasin. A ce titre, les pharmacies peuvent en toute légalité vendre des produits contenant du CBD tant que ces derniers restent dans la catégorie des compléments alimentaires. Toutefois, mis à part quelques parapharmacies, les produits au CBD se font encore rares dans les pharmacies françaises.

 

References:

  1. Order of August 22, 1990 implementing Article R. 5132-86 of the Public Health Code for cannabis: https: //www.legifrance.gouv.fr/loda/id/JORFTEXT000000351447/2020-10-09/
  2. WHO Committee Report, November 2017: https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf
  3. ANSM epilepsy and CBD briefing on January 11, 2019: https://ansm.sante.fr/S-informer/Points-d-information-Points-d-information/Epilepsie-l-ANSM-alerte-sur-les-dangers-lies-a-l-utilisation-de-produits-contenant-du-cannabidiol-vendus-notamment-sur-Internet-Point-d-information
  4. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model by Laura E. Ewing 1,2, Charles M. Skinner 1,3, Charles M. Quick 4, Stefanie Kennon-McGill 1, Mitchell R. McGill 1,2,3, Larry A. Walker 5,6, Mahmoud A. ElSohly 5,6,7, Bill J. Gurley 3,8 and Igor Koturbash 1,3, Study published in the journal Molecule, April 2019: https://www.mdpi.com/1420-3049/24/9/1694/htm